Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
747 |
N |
789 |
D |
0.93 |
2 |
749 |
L |
787 |
T |
0.79 |
3 |
747 |
N |
754 |
K |
0.77 |
4 |
726 |
G |
768 |
Y |
0.71 |
5 |
652 |
Y |
689 |
T |
0.71 |
6 |
650 |
E |
693 |
L |
0.71 |
7 |
748 |
L |
770 |
F |
0.68 |
8 |
728 |
K |
788 |
E |
0.68 |
9 |
667 |
S |
671 |
T |
0.67 |
10 |
648 |
K |
694 |
T |
0.65 |
11 |
749 |
L |
754 |
K |
0.65 |
12 |
650 |
E |
691 |
E |
0.64 |
13 |
666 |
E |
670 |
W |
0.61 |
14 |
664 |
L |
672 |
H |
0.61 |
15 |
628 |
T |
671 |
T |
0.61 |
16 |
695 |
K |
699 |
Y |
0.59 |
17 |
816 |
V |
820 |
W |
0.57 |
18 |
652 |
Y |
691 |
E |
0.57 |
19 |
852 |
N |
856 |
N |
0.56 |
20 |
665 |
N |
670 |
W |
0.56 |
21 |
647 |
I |
696 |
V |
0.55 |
22 |
645 |
T |
668 |
N |
0.55 |
23 |
750 |
A |
782 |
I |
0.54 |
24 |
648 |
K |
663 |
I |
0.54 |
25 |
747 |
N |
787 |
T |
0.53 |
26 |
631 |
K |
692 |
E |
0.52 |
27 |
647 |
I |
695 |
K |
0.50 |
28 |
711 |
L |
715 |
N |
0.49 |
29 |
629 |
V |
672 |
H |
0.48 |
30 |
837 |
E |
845 |
T |
0.48 |
31 |
664 |
L |
674 |
W |
0.47 |
32 |
651 |
L |
674 |
W |
0.47 |
33 |
849 |
A |
859 |
H |
0.46 |
34 |
670 |
W |
674 |
W |
0.46 |
35 |
632 |
N |
636 |
N |
0.46 |
36 |
857 |
W |
864 |
L |
0.45 |
37 |
926 |
K |
930 |
K |
0.45 |
38 |
762 |
S |
766 |
W |
0.44 |
39 |
725 |
S |
767 |
K |
0.44 |
40 |
830 |
R |
851 |
L |
0.44 |
41 |
628 |
T |
673 |
T |
0.44 |
42 |
649 |
V |
692 |
E |
0.44 |
43 |
790 |
H |
794 |
Y |
0.43 |
44 |
650 |
E |
657 |
A |
0.42 |
45 |
851 |
L |
855 |
N |
0.42 |
46 |
751 |
D |
777 |
D |
0.42 |
47 |
775 |
K |
781 |
K |
0.42 |
48 |
746 |
V |
788 |
E |
0.41 |
49 |
705 |
N |
710 |
N |
0.41 |
50 |
727 |
E |
767 |
K |
0.40 |
51 |
837 |
E |
844 |
A |
0.40 |
52 |
725 |
S |
769 |
E |
0.40 |
53 |
857 |
W |
861 |
W |
0.40 |
54 |
686 |
V |
690 |
V |
0.40 |
55 |
750 |
A |
755 |
V |
0.40 |
56 |
677 |
L |
688 |
Y |
0.39 |
57 |
744 |
V |
791 |
V |
0.39 |
58 |
666 |
E |
672 |
H |
0.39 |
59 |
760 |
V |
770 |
F |
0.38 |
60 |
626 |
S |
673 |
T |
0.38 |
61 |
837 |
E |
848 |
T |
0.38 |
62 |
812 |
T |
820 |
W |
0.38 |
63 |
747 |
N |
757 |
T |
0.38 |
64 |
841 |
D |
846 |
G |
0.38 |
65 |
853 |
E |
857 |
W |
0.38 |
66 |
653 |
Q |
688 |
Y |
0.37 |
67 |
688 |
Y |
693 |
L |
0.37 |
68 |
653 |
Q |
658 |
T |
0.37 |
69 |
760 |
V |
764 |
T |
0.37 |
70 |
630 |
T |
634 |
D |
0.37 |
71 |
720 |
E |
775 |
K |
0.37 |
72 |
835 |
K |
848 |
T |
0.37 |
73 |
812 |
T |
816 |
V |
0.37 |
74 |
730 |
W |
744 |
V |
0.36 |
75 |
630 |
T |
643 |
R |
0.36 |
76 |
761 |
T |
766 |
W |
0.36 |
77 |
692 |
E |
699 |
Y |
0.36 |
78 |
776 |
Y |
781 |
K |
0.36 |
79 |
823 |
N |
827 |
D |
0.35 |
80 |
633 |
W |
637 |
N |
0.35 |
81 |
814 |
A |
818 |
K |
0.35 |
82 |
651 |
L |
690 |
V |
0.35 |
83 |
627 |
A |
690 |
V |
0.34 |
84 |
745 |
S |
790 |
H |
0.34 |
85 |
631 |
K |
649 |
V |
0.34 |
86 |
861 |
W |
877 |
V |
0.34 |
87 |
763 |
E |
767 |
K |
0.33 |
88 |
745 |
S |
757 |
T |
0.33 |
89 |
845 |
T |
859 |
H |
0.33 |
90 |
748 |
L |
784 |
Y |
0.33 |
91 |
749 |
L |
785 |
T |
0.33 |
92 |
648 |
K |
665 |
N |
0.32 |
93 |
820 |
W |
834 |
I |
0.32 |
94 |
646 |
E |
665 |
N |
0.32 |
95 |
723 |
S |
771 |
K |
0.32 |
96 |
836 |
V |
857 |
W |
0.32 |
97 |
711 |
L |
716 |
K |
0.32 |
98 |
840 |
Q |
844 |
A |
0.32 |
99 |
628 |
T |
634 |
D |
0.32 |
100 |
832 |
T |
838 |
L |
0.32 |
101 |
820 |
W |
825 |
N |
0.32 |
102 |
746 |
V |
768 |
Y |
0.32 |
103 |
688 |
Y |
784 |
Y |
0.31 |
104 |
630 |
T |
671 |
T |
0.31 |
105 |
632 |
N |
637 |
N |
0.31 |
106 |
749 |
L |
755 |
V |
0.31 |
107 |
705 |
N |
709 |
G |
0.31 |
108 |
722 |
T |
726 |
G |
0.31 |
109 |
726 |
G |
760 |
V |
0.31 |
110 |
740 |
R |
744 |
V |
0.31 |
111 |
743 |
K |
759 |
D |
0.30 |
112 |
686 |
V |
699 |
Y |
0.30 |
113 |
686 |
V |
694 |
T |
0.30 |
114 |
633 |
W |
638 |
N |
0.30 |
115 |
667 |
S |
763 |
E |
0.30 |
116 |
839 |
Y |
844 |
A |
0.30 |
117 |
760 |
V |
768 |
Y |
0.30 |
118 |
672 |
H |
768 |
Y |
0.30 |
119 |
777 |
D |
782 |
I |
0.30 |
120 |
651 |
L |
688 |
Y |
0.30 |
121 |
791 |
V |
796 |
T |
0.30 |
122 |
766 |
W |
770 |
F |
0.30 |
123 |
631 |
K |
637 |
N |
0.30 |
124 |
643 |
R |
649 |
V |
0.29 |
125 |
846 |
G |
850 |
I |
0.29 |
126 |
647 |
I |
651 |
L |
0.29 |
127 |
649 |
V |
690 |
V |
0.29 |
128 |
670 |
W |
677 |
L |
0.29 |
129 |
852 |
N |
857 |
W |
0.29 |
130 |
861 |
W |
875 |
Y |
0.29 |
131 |
832 |
T |
836 |
V |
0.29 |
132 |
654 |
D |
658 |
T |
0.29 |
133 |
688 |
Y |
694 |
T |
0.28 |
134 |
626 |
S |
675 |
T |
0.28 |
135 |
723 |
S |
769 |
E |
0.28 |
136 |
796 |
T |
801 |
T |
0.28 |
137 |
838 |
L |
875 |
Y |
0.28 |
138 |
648 |
K |
693 |
L |
0.28 |
139 |
776 |
Y |
782 |
I |
0.28 |
140 |
770 |
F |
786 |
V |
0.28 |
141 |
746 |
V |
766 |
W |
0.28 |
142 |
816 |
V |
821 |
D |
0.28 |
143 |
730 |
W |
734 |
D |
0.28 |
144 |
686 |
V |
693 |
L |
0.28 |
145 |
690 |
V |
694 |
T |
0.28 |
146 |
726 |
G |
770 |
F |
0.27 |
147 |
645 |
T |
667 |
S |
0.27 |
148 |
721 |
T |
772 |
D |
0.27 |
149 |
685 |
Q |
694 |
T |
0.27 |
150 |
812 |
T |
818 |
K |
0.27 |
151 |
787 |
T |
798 |
I |
0.27 |
152 |
840 |
Q |
875 |
Y |
0.27 |
153 |
817 |
T |
821 |
D |
0.27 |
154 |
840 |
Q |
845 |
T |
0.27 |
155 |
629 |
V |
649 |
V |
0.27 |
156 |
633 |
W |
647 |
I |
0.27 |
157 |
861 |
W |
865 |
D |
0.27 |
158 |
818 |
K |
822 |
D |
0.27 |
159 |
851 |
L |
863 |
G |
0.27 |
160 |
851 |
L |
856 |
N |
0.27 |
161 |
633 |
W |
644 |
P |
0.27 |
162 |
773 |
L |
777 |
D |
0.27 |
163 |
629 |
V |
636 |
N |
0.27 |
164 |
651 |
L |
672 |
H |
0.26 |
165 |
757 |
T |
848 |
T |
0.26 |
166 |
760 |
V |
766 |
W |
0.26 |
167 |
761 |
T |
765 |
N |
0.26 |
168 |
836 |
V |
840 |
Q |
0.26 |
169 |
645 |
T |
649 |
V |
0.26 |
170 |
726 |
G |
802 |
T |
0.26 |
171 |
846 |
G |
853 |
E |
0.26 |
172 |
851 |
L |
857 |
W |
0.26 |
173 |
630 |
T |
635 |
D |
0.26 |
174 |
829 |
K |
834 |
I |
0.26 |
175 |
762 |
S |
853 |
E |
0.26 |
176 |
644 |
P |
649 |
V |
0.26 |
177 |
653 |
Q |
689 |
T |
0.26 |
178 |
838 |
L |
861 |
W |
0.26 |
179 |
846 |
G |
851 |
L |
0.25 |
180 |
820 |
W |
824 |
N |
0.25 |
181 |
842 |
G |
846 |
G |
0.25 |
182 |
860 |
T |
865 |
D |
0.25 |
183 |
708 |
M |
712 |
I |
0.25 |
184 |
701 |
T |
705 |
N |
0.25 |
185 |
834 |
I |
838 |
L |
0.25 |
186 |
849 |
A |
855 |
N |
0.25 |
187 |
829 |
K |
848 |
T |
0.25 |
188 |
845 |
T |
851 |
L |
0.25 |
189 |
853 |
E |
859 |
H |
0.25 |
190 |
631 |
K |
636 |
N |
0.25 |
191 |
649 |
V |
672 |
H |
0.25 |
192 |
724 |
I |
788 |
E |
0.25 |
193 |
830 |
R |
834 |
I |
0.25 |
194 |
841 |
D |
845 |
T |
0.25 |
195 |
730 |
W |
748 |
L |
0.25 |
196 |
721 |
T |
774 |
P |
0.25 |
197 |
647 |
I |
744 |
V |
0.25 |
198 |
685 |
Q |
695 |
K |
0.25 |
199 |
649 |
V |
653 |
Q |
0.25 |
200 |
774 |
P |
788 |
E |
0.25 |
201 |
628 |
T |
636 |
N |
0.25 |
202 |
856 |
N |
866 |
E |
0.25 |
203 |
644 |
P |
648 |
K |
0.25 |
204 |
623 |
G |
628 |
T |
0.24 |
205 |
661 |
T |
674 |
W |
0.24 |
206 |
629 |
V |
634 |
D |
0.24 |
207 |
848 |
T |
853 |
E |
0.24 |
208 |
845 |
T |
855 |
N |
0.24 |
209 |
843 |
K |
866 |
E |
0.24 |
210 |
665 |
N |
672 |
H |
0.24 |
211 |
859 |
H |
866 |
E |
0.24 |
212 |
652 |
Y |
658 |
T |
0.24 |
213 |
728 |
K |
803 |
I |
0.24 |
214 |
722 |
T |
776 |
Y |
0.24 |
215 |
653 |
Q |
678 |
D |
0.24 |
216 |
811 |
E |
818 |
K |
0.24 |
217 |
758 |
L |
766 |
W |
0.24 |
218 |
631 |
K |
635 |
D |
0.24 |
219 |
652 |
Y |
657 |
A |
0.24 |
220 |
816 |
V |
824 |
N |
0.24 |
221 |
838 |
L |
863 |
G |
0.24 |
222 |
843 |
K |
859 |
H |
0.24 |
223 |
649 |
V |
670 |
W |
0.24 |
224 |
829 |
K |
862 |
T |
0.24 |
225 |
851 |
L |
859 |
H |
0.24 |
226 |
833 |
E |
853 |
E |
0.24 |
227 |
651 |
L |
664 |
L |
0.24 |
228 |
859 |
H |
875 |
Y |
0.24 |
229 |
856 |
N |
861 |
W |
0.24 |
230 |
693 |
L |
698 |
G |
0.24 |
231 |
692 |
E |
696 |
V |
0.24 |
232 |
644 |
P |
696 |
V |
0.24 |
233 |
859 |
H |
865 |
D |
0.24 |
234 |
833 |
E |
850 |
I |
0.24 |
235 |
856 |
N |
863 |
G |
0.23 |
236 |
836 |
V |
866 |
E |
0.23 |
237 |
851 |
L |
861 |
W |
0.23 |
238 |
849 |
A |
853 |
E |
0.23 |
239 |
828 |
G |
832 |
T |
0.23 |
240 |
703 |
V |
707 |
D |
0.23 |
241 |
834 |
I |
839 |
Y |
0.23 |
242 |
724 |
I |
728 |
K |
0.23 |
243 |
866 |
E |
877 |
V |
0.23 |
244 |
858 |
T |
865 |
D |
0.23 |
245 |
792 |
K |
796 |
T |
0.23 |
246 |
636 |
N |
643 |
R |
0.23 |
247 |
629 |
V |
633 |
W |
0.23 |
248 |
837 |
E |
859 |
H |
0.23 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation